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The temptation to escalate the dose because “nothing is happening yet” is exactly the mistake the timeline section is designed to head off — the mechanism is cumulative, not dose-chased

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High homocysteine not responding to methylfolate : A 2023 RCT found people with MTHFR C677T had better homocysteine balance with folinic acid than methylfolate.²⁷ Who Should Avoid Folinic Acid: MTHFS Variants The MTHFS enzyme converts folinic acid into other usable folate forms